Does smoking predispose to DVT?

[القصرعينية]

most of us know that smoking is a major risk factor for arteial diseases (e.g.atherosclerosis, burger's, Myocardial infarction,..etc)

,BUT does smoking have the same effect on veins?


:bold:

[Nabilsabri]

Smoking and DVT
Cigarette smoking increases blood clotting (hypercoagulability).
one of Three factors which increase the chance of having a DVTwhich is
Injury to a deep vein from trauma or surgery
Poor blood circulation in the deep veins
Conditions that increase the tendency of blood to clot

دا اللى فى مخى دلوقتى

[القصرعينية]

TABLE 1. Potential procoagulant mechanisms that may be associated with smoking



<TABLE width="100%" border=1><TBODY><TR><TD><TABLE cellSpacing=10 cellPadding=0 width="100%"><TBODY><TR><TD vAlign=bottom align=left><HR noShade SIZE=1>• Increased fibrinogen levels from:<SUP> </SUP>
Increased interleukin-6<SUP> </SUP>
Increased catecholamine release<SUP> </SUP>
Free fatty acids</TD><TD vAlign=bottom align=left><HR noShade SIZE=1></TD></TR><TR><TD colSpan=2><HR></TD></TR><TR><TD vAlign=bottom align=left>• Increased clotting factor levels including factors II (thrombin), V, VIII, X, and XIII</TD><TD vAlign=bottom align=left></TD></TR><TR><TD vAlign=bottom align=left>• Increased tissue factor level</TD><TD vAlign=bottom align=left></TD></TR><TR><TD vAlign=bottom align=left>• Reduced tissue factor pathway inhibitor level</TD><TD vAlign=bottom align=left></TD></TR><TR><TD vAlign=bottom align=left>• Increased homocysteine level</TD><TD vAlign=bottom align=left></TD></TR><TR><TD vAlign=bottom align=left>• Lower antithrombin III activity</TD><TD vAlign=bottom align=left></TD></TR><TR><TD vAlign=bottom align=left>• Impaired fibrinolysis<SUP> </SUP>
Reduced tissue plasminogen activator production<SUP> </SUP>
Impaired tissue plasminogen activator release<SUP> </SUP>
Increased plasminogen activator inhibitor production</TD><TD vAlign=bottom align=left></TD></TR><TR><TD vAlign=bottom align=left>• Increased platelet activation
<HR noShade SIZE=1></TD><TD vAlign=bottom align=left>
<HR noShade SIZE=1></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE><!-- tblfn -->The above mechanisms are interrelated. It is difficult to be certain which abnormalities both clearly result from smoking and also clinically increase the risk for venous thrombosis. Some, particularly the D-dimer level, are more likely to simply represent markers of thrombosis.

[nabilprofelgen]

هو دى دايمر بيتقاس فى الدم و لا فى البول؟

[القصرعينية]

D-dimer is one of the fibrin degradation products detected in the blood.

[nabilprofelgen]

<TABLE cellSpacing=5 cellPadding=5 width=755 border=0><TBODY><TR bgColor=#ccff99><TD class=Normal vAlign=top align=middle width="4%">168

</TD><TD class=Normal vAlign=top width="27%">FDP (D-Dimer)

</TD><TD class=Normal vAlign=top width="16%">
2ml citrated plasma

</TD><TD class=Normal vAlign=top width="10%">
Freeze

</TD><TD class=Normal vAlign=top width="15%">
--

</TD><TD class=Normal vAlign=top width="24%">
FDP= Fibrinogen Degradation Product

</TD></TR></TBODY></TABLE>


From http://www.malariadiagnosis.com/html/alphalist/1-a.htm
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