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17-02-2007, 02:35 PM
Addison’s Disease primary adrenocortical deficiency; cortisol, aldosterone
Addisonian Anemia pernicious anemia (antibodies to intrinsic factor or parietal cells IF Vit B12 megaloblastic anemia)
Albright’s Syndrome polyostotic fibrous dysplasia, precocious puberty, café au lait spots, short stature, young girls
Alport’s Syndrome hereditary nephritis with nerve deafness
Alzheimer’s progressive dementia
Argyll-Robertson Pupil loss of light reflex constriction (contralateral or bilateral)
“Prostitute’s Eye” - accommodates but does not react
Pathognomonic for 3Syphilis
Arnold-Chiari Malformation cerebellar tonsil herniation
Barrett’s adenocarcinoma columnar metaplasia of lower esophagus (* risk of adenocarcinoma)
Bartter’s Syndrome hyperreninemia
Becker’s Muscular Dystrophy similar to Duchenne, but less severe (deficiency in dystrophin protein)
Bell’s Palsy CNVII palsy (entire face; recall that UMN lesion only affects lower face)
Berger’s Disease IgA nephropathy
Bernard-Soulier Disease defect in platelet adhesion (abnormally large platelets & lack of platelet-surface glycoprotein)
Berry Aneurysm circle of Willis (subarachnoid bleed)
often associated with ADPKD
Bowen’s Disease carcinoma in situ on shaft of penis (* risk of visceral ca)
Boerhaave's syndrome complete rupture of the esophagus
Briquet’s Syndrome somatization disorder
psychological: multiple physical complaints without physical pathology
Broca’s Aphasia Motor Aphasia intact comprehension
Brown-Sequard hemisection of cord (contralateral loss of pain & temp / ipsilateral loss of fine touch, UMN)
Bruton’s Disease X-linked agammaglobinemia
Budd-Chiari post-hepatic venous thrombosis
Buerger’s Disease acute inflammation of small, medium arteries * painful ischemia * gangrene
Burkitt’s Lymphoma small noncleaved cell lymphoma EBV
8:14 translocation
Caisson Disease gas emboli
Chagas’ Disease Trypansoma infection sleeping disease, cardiomegaly with apical atrophy, achlasia
Chediak-Higashi Disease Primary defect is in assembly of microtubules.
Phagocyte Deficiency: neutropenia, albinism, cranial & peripheral neuropathy w repeated infections
Conn’s Syndrome primary hyperaldosteronism
Cori’s Disease glycogen storage disease (debranching enzyme deficiency)
Creutzfeldt-Jakob prion infection * cerebellar & cerebral degeneration
Crigler-Najjar Syndrome congenital hyperbilirubinemia (unconjugated)
glucuronyl transferase deficiency
Crohn’s IBD; ileocecum, transmural, skip lesions, lymphocytic infiltrate, granulomas
(contrast to UC: limited to colon, mucosa & submucosa, crypt abscesses, pseudopolyps, * colon cancer risk)
Curling’s Ulcer acute gastric ulcer associated with severe burns
Cushing’s Disease: hypercorticism 2* to * ACTH from pituitary (basophilic adenoma)
Syndrome: hypercorticism of all other causes (1* adrenal or ectopic ACTH or ectopic cortisol)
Cushing’s Ulcer acute gastric ulcer associated with CNS trauma
de Quervain’s Thyroiditis self-limiting focal destruction (subacute thyroiditis)
DiGeorge’s Syndrome thymic hypoplasia * T-cell deficiency
hypoparathyroidism
Down’s Syndrome trisomy 21 or translocation
Dressler’s Syndrome Post-MI Fibrinous Pericarditis autoimmune
Dubin-Johnson Syndrome congenital hyperbilirubinemia (conjugated)
striking brown-to-black discoloration of the liver
Duchenne Muscular Dystrophy deficiency of dystrophin protein * MD X-linked recessive
Edwards’ Syndrome trisomy 18
rocker-bottom feet, low ears, heart disease
Ehler’s-Danlos defective collagen
Eisenmenger’s Complex late cyanotic shunt (RL) pulmonary HTN & RVH 2 to long-standing VSD, ASD, or PDA
Erb-Duchenne Palsy trauma to superior trunk of brachial plexus Waiter’s Tip
Ewing Sarcoma undifferentiated round cell tumor of bone
Euthyroid sick syndrome Circulating T3 decrease while rT3 increases . Type I 5' deiodinase is inhibited by metabolic shock. Type II 5' monodeiodinase still functions so the hypothalamic feeedback mechanism doesn't see the problem.
Eyrthroplasia of Queyrat carcinoma in situ on glans penis
Fanconi’s Syndrome impaired proximal tubular reabsorption 2* to lead poisoning or Tetracycline (glycosuria, hyperphosphaturia, aminoaciduria, systemic acidosis)
Felty’s Syndrome rheumatoid arthritis, neutropenia, splenomegaly
Gardner’s Syndrome adenomatous polyps of colon plus osteomas & soft tissue tumors
Gaucher’s Disease Lysosomal Storage Disease glucocerebrosidase deficiency
hepatosplenomegaly, femoral head & long bone erosion, anemia
Gilbert’s Syndrome benign congenital hyperbilirubinemia (unconjugated)
Glanzmann's Thrombasthenia defective glycoproteins on platelets
Goodpasture’s autoimmune: ab’s to glomerular & alveolar basement membranes
Grave’s Disease autoimmune hyperthyroidism (TSI)
Guillain-Barre idiopathic polyneuritis (ascending muscle weakness & paralysis; usually self-limiting)
Hamman-Rich Syndrome idiopathic pulmonary fibrosis
Hand-Schuller-Christian chronic progressive histiocytosis
Hashimoto’s Thyroiditis autoimmune hypothyroidism; #1 cause of hypothyroidism
Hashitoxicosis initial hyperthyroidism in Hashimoto’s Thyroiditis that precedes hypothyroidism
Henoch-Schonlein purpura hypersensivity vasculitis
hemmorhagic urticaria (with fever, arthralgias, GI & renal involvement)
associated with upper respiratory infections
Hirschprung’s Disease aganglionic megacolon
Horner’s Syndrome ptosis, miosis, anhidrosis (lesion of cervical sympathetic nerves often 2* to a Pancoast tumor)
Huntington’s progressive degeneration of caudate nucleus, putamen & frontal cortex; AD
Jacksonian Seizures epileptic events originating in the primary motor cortex (area 4)
Job’s Syndrome immune deficiency: neutrophils fail to respond to chemotactic stimuli
Kaposi Sarcoma malignant vascular tumor (HHV8 in homo***ual men)
Kartagener’s Syndrome immotile cilia 2 to defective dynein arms infection, situs inversus, sterility
Kawasaki Disease mucocutaneous lymph node syndrome (lips, oral mucosa)
Klinefelter’s Syndrome 47, XXY
Kluver-Bucy bilateral lesions of amygdala (hyper***uality; oral behavior)
Krukenberg Tumor adenocarcinoma with signet-ring cells (typically originating from the stomach) metastases to the ovaries
Laennec’s Cirrhosis alcoholic cirrhosis
Lesch-Nyhan HGPRT deficiency
gout, retardation, self-mutilation
Letterer-Siwe acute disseminated Langerhans’ cell histiocytosis
Libman-Sacks endocarditis with small vegetations on valve leaflets
associated with SLE
Lou Gehrig’s Amyotrophic Lateral Sclerosis degeneration of upper & lower motor neurons
Lynch syndrome autosomal dominant familial colorectal CA
Mallory-Weis Syndrome bleeding from esophagogastric lacerations 2* to wretching (alcoholics)
Marfan’s connective tissue defect
McArdle’s Disease glycogen storage disease (muscle phosphorylase deficiency)
Meckel’s Diverticulum rule of 2’s: 2 inches long, 2 feet from the ileocecum, in 2% of the population
embryonic duct origin; may contain ectopic tissue (gastric, pancreatic, etc.)
Meig’s Syndrome Triad: ovarian fibroma, ascites, hydrothorax
MEN IIa medullary CA of thyroid, primary hyperparathyroidism, pheochromacytoma
MEN IIb medullary CA of thyroid, mucosal neuroma of lips, pheochromacytoma
Menetrier’s Disease giant hypertrophic gastritis (enlarged rugae; plasma protein loss)
Methemoglobinemia chocolate brown blood cyanosis unresponsive to oxygen therapy. Give methylene blue.
Monckeberg’s Arteriosclerosis calcification of the media (usually radial & ulnar aa.)
Munchausen Syndrome factitious disorder (consciously creates symptoms, but doesn’t know why)
Nelson’s Syndrome 1* Adrenal Cushings * surgical removal of adrenals * loss of negative feedback to pituitary * Pituitary Adenoma
Niemann-Pick Lysosomal Storage Disease sphingomyelinase deficiency
“foamy histiocytes”
Osler-Weber-Rendu Syndrome Hereditary Hemorrhagic Telangiectasia
Paget’s Disease abnormal bone architecture (thickened, numerous fractures * pain)
Pancoast Tumor bronchogenic tumor with superior sulcus involvement * Horner’s Syndrome
Parkinson’s dopamine depletion in nigrostriatal tracts
Peutz-Jegher’s Syndrome melanin pigmentation of lips, mouth, hand, genitalia plus hamartomatous polyps of small intestine
Peyronie’s Disease subcutaneous fibrosis of dorsum of penis
Pick’s Disease progressive dementia similar to Alzheimer’s
Plummer’s Syndrome hyperthyroidism, nodular goiter, absence of eye signs (Plummer’s = Grave’s - eye signs)
Plummer-Vinson esophageal webs & iron-deficiency anemia, SCCA of esophagus
Pompe’s Disease glycogen storage disease * cardiomegaly
Pott’s Disease tuberculous osteomyelitis of the vertebrae
Potter’s Complex renal agenesis * oligohydramnios * hypoplastic lungs, defects in extremities
Raynaud’s Disease: recurrent vasospasm in extremities
Phenomenon: 2* to underlying disease (SLE or scleroderma)
Reiter’s Syndrome urethritis, conjunctivitis, arthritis non-infectious (but often follows infections), HLA-B27, polyarticular
Reye’s Syndrome microvesicular fatty liver change & encephalopathy
2* to aspirin ingestion in children following viral illness
Riedel’s Thyroiditis idiopathic fibrous replacement of thyroid
Rotor Syndrome congenital hyperbilirubinemia (conjugated)
similar to Dubin-Johnson, but no discoloration of the liver
Sezary Syndrome leukemic form of cutaneous T-cell lymphoma (mycosis fungoides)
Shaver’s Disease aluminum inhalation lung fibrosis
Sheehan’s Syndrome postpartum pituitary necrosis
Shy-Drager parkinsonism with autonomic dysfunction & orthostatic hypotension
Simmond’s Disease pituitary cachexia
Sipple’s Syndrome MEN type IIa (pheochromocytoma, thyroid medulla, parathyroid)
Sjogren’s Syndrome triad: dry eyes, dry mouth, arthritis risk of B-cell lymphoma
Spherocytosis Defect of spectrin resulting in spherical RBCs
results in hemolytic anemias
Spitz Nevus juvenile melanoma (always benign)
Stein-Leventhal polycystic ovary
Stevens-Johnson Syndrome erythema multiforme, fever, malaise, mucosal ulceration (often 2 to infection or sulfa drugs)
Still’s Disease juvenile rheumatoid arthritis (absence of rheumatoid factor)
Takayasu’s arteritis aortic arch syndrome
loss of carotid, radial or ulnar pulses
Tay-Sachs gangliosidosis (hexosaminidase A deficiency * GM2 ganglioside)
Tetralogy of Fallot ÊVSD, Ëoverriding aorta, Ìpulmonary artery stenosis, Íright ventricular hypertrophy
Tourette’s Syndrome involuntary actions, both motor and vocal
Turcot’s Syndrome adenomatous polyps of colon plus CNS tumors
Turner’s Syndrome 45, XO
Vincent’s Infection “trench mouth” - acute necrotizing ulcerative gingivitis
von Gierke’s Disease glycogen storage disease (G6Pase deficiency)
von Hippel-Lindau hemangioma (or hemangioblastoma)
adenomas of the viscera, especially renal cell carcinoma
von Recklinghausen’s neurofibromatosis & café au lait spots
von Recklinghausen’s Disease of Bone osteitis fibrosa cystica (“brown tumor”) 2* to hyperparathyroidism
von Willebrand’s Disease defect in platelet adhesion 2* to deficiency in vWF
Waldenstrom’s macroglobinemia proliferation of IgM-producing lymphoid cells
Wallenberg’s Syndrome Posterior Inferior Cerebellar Artery (PICA) thrombosis “Medullary Syndrome”
Ipsilateral: ataxia, facial pain & temp; Contralateral: body pain & temp
Waterhouse-Friderichsen catastrophic adrenal insufficiency 2* to hemorrhagic necrosis (eg, DIC)
often 2* to meningiococcemia
Weber’s Syndrome Paramedian Infarct of Midbrain
Ipsilateral: mydriasis; Contralateral: UMN paralysis (lower face & body)
Wegener’s Granulomatosis necrotizing granulomatous vasculitis of paranasal sinuses, lungs, kidneys, etc.
Weil’s Disease leptospirosis
Wermer’s Syndrome MEN type I (thyroid, parathyroid, adrenal cortex, pancreatic islets, pituitary)
Wernicke’s Aphasia Sensory Aphasia impaired comprehension
Wernicke-Korsakoff Syndrome thiamine deficiency in alcoholics; bilateral mamillary bodies (confusion, ataxia, ophthalmoplegia)
Whipple’s Disease malabsorption syndrome (with bacteria-laden macrophages) & polyarthritis
Wilson’s Disease hepatolenticular degeneration (copper accumulation & decrease in ceruloplasmin)
Wiskott-Aldrich Syndrome immunodeficiency: combined B- &T-cell deficiency (thrombocytopenia & eczema)
Wolff-Chaikoff Effect high iodine level (*)’s thyroid hormone synthesis
Zenker’s Diverticulum esophageal; cricopharyngeal muscles above UES
Zollinger-Ellison gastrin-secreting tumor of pancreas (or intestine) * * acid * intractable ulcers
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Addisonian Anemia pernicious anemia (antibodies to intrinsic factor or parietal cells IF Vit B12 megaloblastic anemia)
Albright’s Syndrome polyostotic fibrous dysplasia, precocious puberty, café au lait spots, short stature, young girls
Alport’s Syndrome hereditary nephritis with nerve deafness
Alzheimer’s progressive dementia
Argyll-Robertson Pupil loss of light reflex constriction (contralateral or bilateral)
“Prostitute’s Eye” - accommodates but does not react
Pathognomonic for 3Syphilis
Arnold-Chiari Malformation cerebellar tonsil herniation
Barrett’s adenocarcinoma columnar metaplasia of lower esophagus (* risk of adenocarcinoma)
Bartter’s Syndrome hyperreninemia
Becker’s Muscular Dystrophy similar to Duchenne, but less severe (deficiency in dystrophin protein)
Bell’s Palsy CNVII palsy (entire face; recall that UMN lesion only affects lower face)
Berger’s Disease IgA nephropathy
Bernard-Soulier Disease defect in platelet adhesion (abnormally large platelets & lack of platelet-surface glycoprotein)
Berry Aneurysm circle of Willis (subarachnoid bleed)
often associated with ADPKD
Bowen’s Disease carcinoma in situ on shaft of penis (* risk of visceral ca)
Boerhaave's syndrome complete rupture of the esophagus
Briquet’s Syndrome somatization disorder
psychological: multiple physical complaints without physical pathology
Broca’s Aphasia Motor Aphasia intact comprehension
Brown-Sequard hemisection of cord (contralateral loss of pain & temp / ipsilateral loss of fine touch, UMN)
Bruton’s Disease X-linked agammaglobinemia
Budd-Chiari post-hepatic venous thrombosis
Buerger’s Disease acute inflammation of small, medium arteries * painful ischemia * gangrene
Burkitt’s Lymphoma small noncleaved cell lymphoma EBV
8:14 translocation
Caisson Disease gas emboli
Chagas’ Disease Trypansoma infection sleeping disease, cardiomegaly with apical atrophy, achlasia
Chediak-Higashi Disease Primary defect is in assembly of microtubules.
Phagocyte Deficiency: neutropenia, albinism, cranial & peripheral neuropathy w repeated infections
Conn’s Syndrome primary hyperaldosteronism
Cori’s Disease glycogen storage disease (debranching enzyme deficiency)
Creutzfeldt-Jakob prion infection * cerebellar & cerebral degeneration
Crigler-Najjar Syndrome congenital hyperbilirubinemia (unconjugated)
glucuronyl transferase deficiency
Crohn’s IBD; ileocecum, transmural, skip lesions, lymphocytic infiltrate, granulomas
(contrast to UC: limited to colon, mucosa & submucosa, crypt abscesses, pseudopolyps, * colon cancer risk)
Curling’s Ulcer acute gastric ulcer associated with severe burns
Cushing’s Disease: hypercorticism 2* to * ACTH from pituitary (basophilic adenoma)
Syndrome: hypercorticism of all other causes (1* adrenal or ectopic ACTH or ectopic cortisol)
Cushing’s Ulcer acute gastric ulcer associated with CNS trauma
de Quervain’s Thyroiditis self-limiting focal destruction (subacute thyroiditis)
DiGeorge’s Syndrome thymic hypoplasia * T-cell deficiency
hypoparathyroidism
Down’s Syndrome trisomy 21 or translocation
Dressler’s Syndrome Post-MI Fibrinous Pericarditis autoimmune
Dubin-Johnson Syndrome congenital hyperbilirubinemia (conjugated)
striking brown-to-black discoloration of the liver
Duchenne Muscular Dystrophy deficiency of dystrophin protein * MD X-linked recessive
Edwards’ Syndrome trisomy 18
rocker-bottom feet, low ears, heart disease
Ehler’s-Danlos defective collagen
Eisenmenger’s Complex late cyanotic shunt (RL) pulmonary HTN & RVH 2 to long-standing VSD, ASD, or PDA
Erb-Duchenne Palsy trauma to superior trunk of brachial plexus Waiter’s Tip
Ewing Sarcoma undifferentiated round cell tumor of bone
Euthyroid sick syndrome Circulating T3 decrease while rT3 increases . Type I 5' deiodinase is inhibited by metabolic shock. Type II 5' monodeiodinase still functions so the hypothalamic feeedback mechanism doesn't see the problem.
Eyrthroplasia of Queyrat carcinoma in situ on glans penis
Fanconi’s Syndrome impaired proximal tubular reabsorption 2* to lead poisoning or Tetracycline (glycosuria, hyperphosphaturia, aminoaciduria, systemic acidosis)
Felty’s Syndrome rheumatoid arthritis, neutropenia, splenomegaly
Gardner’s Syndrome adenomatous polyps of colon plus osteomas & soft tissue tumors
Gaucher’s Disease Lysosomal Storage Disease glucocerebrosidase deficiency
hepatosplenomegaly, femoral head & long bone erosion, anemia
Gilbert’s Syndrome benign congenital hyperbilirubinemia (unconjugated)
Glanzmann's Thrombasthenia defective glycoproteins on platelets
Goodpasture’s autoimmune: ab’s to glomerular & alveolar basement membranes
Grave’s Disease autoimmune hyperthyroidism (TSI)
Guillain-Barre idiopathic polyneuritis (ascending muscle weakness & paralysis; usually self-limiting)
Hamman-Rich Syndrome idiopathic pulmonary fibrosis
Hand-Schuller-Christian chronic progressive histiocytosis
Hashimoto’s Thyroiditis autoimmune hypothyroidism; #1 cause of hypothyroidism
Hashitoxicosis initial hyperthyroidism in Hashimoto’s Thyroiditis that precedes hypothyroidism
Henoch-Schonlein purpura hypersensivity vasculitis
hemmorhagic urticaria (with fever, arthralgias, GI & renal involvement)
associated with upper respiratory infections
Hirschprung’s Disease aganglionic megacolon
Horner’s Syndrome ptosis, miosis, anhidrosis (lesion of cervical sympathetic nerves often 2* to a Pancoast tumor)
Huntington’s progressive degeneration of caudate nucleus, putamen & frontal cortex; AD
Jacksonian Seizures epileptic events originating in the primary motor cortex (area 4)
Job’s Syndrome immune deficiency: neutrophils fail to respond to chemotactic stimuli
Kaposi Sarcoma malignant vascular tumor (HHV8 in homo***ual men)
Kartagener’s Syndrome immotile cilia 2 to defective dynein arms infection, situs inversus, sterility
Kawasaki Disease mucocutaneous lymph node syndrome (lips, oral mucosa)
Klinefelter’s Syndrome 47, XXY
Kluver-Bucy bilateral lesions of amygdala (hyper***uality; oral behavior)
Krukenberg Tumor adenocarcinoma with signet-ring cells (typically originating from the stomach) metastases to the ovaries
Laennec’s Cirrhosis alcoholic cirrhosis
Lesch-Nyhan HGPRT deficiency
gout, retardation, self-mutilation
Letterer-Siwe acute disseminated Langerhans’ cell histiocytosis
Libman-Sacks endocarditis with small vegetations on valve leaflets
associated with SLE
Lou Gehrig’s Amyotrophic Lateral Sclerosis degeneration of upper & lower motor neurons
Lynch syndrome autosomal dominant familial colorectal CA
Mallory-Weis Syndrome bleeding from esophagogastric lacerations 2* to wretching (alcoholics)
Marfan’s connective tissue defect
McArdle’s Disease glycogen storage disease (muscle phosphorylase deficiency)
Meckel’s Diverticulum rule of 2’s: 2 inches long, 2 feet from the ileocecum, in 2% of the population
embryonic duct origin; may contain ectopic tissue (gastric, pancreatic, etc.)
Meig’s Syndrome Triad: ovarian fibroma, ascites, hydrothorax
MEN IIa medullary CA of thyroid, primary hyperparathyroidism, pheochromacytoma
MEN IIb medullary CA of thyroid, mucosal neuroma of lips, pheochromacytoma
Menetrier’s Disease giant hypertrophic gastritis (enlarged rugae; plasma protein loss)
Methemoglobinemia chocolate brown blood cyanosis unresponsive to oxygen therapy. Give methylene blue.
Monckeberg’s Arteriosclerosis calcification of the media (usually radial & ulnar aa.)
Munchausen Syndrome factitious disorder (consciously creates symptoms, but doesn’t know why)
Nelson’s Syndrome 1* Adrenal Cushings * surgical removal of adrenals * loss of negative feedback to pituitary * Pituitary Adenoma
Niemann-Pick Lysosomal Storage Disease sphingomyelinase deficiency
“foamy histiocytes”
Osler-Weber-Rendu Syndrome Hereditary Hemorrhagic Telangiectasia
Paget’s Disease abnormal bone architecture (thickened, numerous fractures * pain)
Pancoast Tumor bronchogenic tumor with superior sulcus involvement * Horner’s Syndrome
Parkinson’s dopamine depletion in nigrostriatal tracts
Peutz-Jegher’s Syndrome melanin pigmentation of lips, mouth, hand, genitalia plus hamartomatous polyps of small intestine
Peyronie’s Disease subcutaneous fibrosis of dorsum of penis
Pick’s Disease progressive dementia similar to Alzheimer’s
Plummer’s Syndrome hyperthyroidism, nodular goiter, absence of eye signs (Plummer’s = Grave’s - eye signs)
Plummer-Vinson esophageal webs & iron-deficiency anemia, SCCA of esophagus
Pompe’s Disease glycogen storage disease * cardiomegaly
Pott’s Disease tuberculous osteomyelitis of the vertebrae
Potter’s Complex renal agenesis * oligohydramnios * hypoplastic lungs, defects in extremities
Raynaud’s Disease: recurrent vasospasm in extremities
Phenomenon: 2* to underlying disease (SLE or scleroderma)
Reiter’s Syndrome urethritis, conjunctivitis, arthritis non-infectious (but often follows infections), HLA-B27, polyarticular
Reye’s Syndrome microvesicular fatty liver change & encephalopathy
2* to aspirin ingestion in children following viral illness
Riedel’s Thyroiditis idiopathic fibrous replacement of thyroid
Rotor Syndrome congenital hyperbilirubinemia (conjugated)
similar to Dubin-Johnson, but no discoloration of the liver
Sezary Syndrome leukemic form of cutaneous T-cell lymphoma (mycosis fungoides)
Shaver’s Disease aluminum inhalation lung fibrosis
Sheehan’s Syndrome postpartum pituitary necrosis
Shy-Drager parkinsonism with autonomic dysfunction & orthostatic hypotension
Simmond’s Disease pituitary cachexia
Sipple’s Syndrome MEN type IIa (pheochromocytoma, thyroid medulla, parathyroid)
Sjogren’s Syndrome triad: dry eyes, dry mouth, arthritis risk of B-cell lymphoma
Spherocytosis Defect of spectrin resulting in spherical RBCs
results in hemolytic anemias
Spitz Nevus juvenile melanoma (always benign)
Stein-Leventhal polycystic ovary
Stevens-Johnson Syndrome erythema multiforme, fever, malaise, mucosal ulceration (often 2 to infection or sulfa drugs)
Still’s Disease juvenile rheumatoid arthritis (absence of rheumatoid factor)
Takayasu’s arteritis aortic arch syndrome
loss of carotid, radial or ulnar pulses
Tay-Sachs gangliosidosis (hexosaminidase A deficiency * GM2 ganglioside)
Tetralogy of Fallot ÊVSD, Ëoverriding aorta, Ìpulmonary artery stenosis, Íright ventricular hypertrophy
Tourette’s Syndrome involuntary actions, both motor and vocal
Turcot’s Syndrome adenomatous polyps of colon plus CNS tumors
Turner’s Syndrome 45, XO
Vincent’s Infection “trench mouth” - acute necrotizing ulcerative gingivitis
von Gierke’s Disease glycogen storage disease (G6Pase deficiency)
von Hippel-Lindau hemangioma (or hemangioblastoma)
adenomas of the viscera, especially renal cell carcinoma
von Recklinghausen’s neurofibromatosis & café au lait spots
von Recklinghausen’s Disease of Bone osteitis fibrosa cystica (“brown tumor”) 2* to hyperparathyroidism
von Willebrand’s Disease defect in platelet adhesion 2* to deficiency in vWF
Waldenstrom’s macroglobinemia proliferation of IgM-producing lymphoid cells
Wallenberg’s Syndrome Posterior Inferior Cerebellar Artery (PICA) thrombosis “Medullary Syndrome”
Ipsilateral: ataxia, facial pain & temp; Contralateral: body pain & temp
Waterhouse-Friderichsen catastrophic adrenal insufficiency 2* to hemorrhagic necrosis (eg, DIC)
often 2* to meningiococcemia
Weber’s Syndrome Paramedian Infarct of Midbrain
Ipsilateral: mydriasis; Contralateral: UMN paralysis (lower face & body)
Wegener’s Granulomatosis necrotizing granulomatous vasculitis of paranasal sinuses, lungs, kidneys, etc.
Weil’s Disease leptospirosis
Wermer’s Syndrome MEN type I (thyroid, parathyroid, adrenal cortex, pancreatic islets, pituitary)
Wernicke’s Aphasia Sensory Aphasia impaired comprehension
Wernicke-Korsakoff Syndrome thiamine deficiency in alcoholics; bilateral mamillary bodies (confusion, ataxia, ophthalmoplegia)
Whipple’s Disease malabsorption syndrome (with bacteria-laden macrophages) & polyarthritis
Wilson’s Disease hepatolenticular degeneration (copper accumulation & decrease in ceruloplasmin)
Wiskott-Aldrich Syndrome immunodeficiency: combined B- &T-cell deficiency (thrombocytopenia & eczema)
Wolff-Chaikoff Effect high iodine level (*)’s thyroid hormone synthesis
Zenker’s Diverticulum esophageal; cricopharyngeal muscles above UES
Zollinger-Ellison gastrin-secreting tumor of pancreas (or intestine) * * acid * intractable ulcers
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